Publications

Product

18 sept. 2024
46 min read
Studies of polyol production by the yeast Yarrowia lipolytica growing on crude glycerol under stressful conditions

Researchers from the University of Athens have successfully harnessed crude glycerol, a biodiesel by-product, as a substrate for producing valuable compounds like polyols and yeast biomass. Their study highlights the adaptability of wild-type Yarrowia lipolytica strains under low pH, low temperature, and non-aseptic conditions, offering a sustainable approach to bio-based production.

18 sept. 202446 min read
Studies of polyol production by the yeast Yarrowia lipolytica growing on crude glycerol under stressful conditions

Researchers from the University of Athens have successfully harnessed crude glycerol, a biodiesel by-product, as a substrate for producing valuable compounds like polyols and yeast biomass. Their study highlights the adaptability of wild-type Yarrowia lipolytica strains under low pH, low temperature, and non-aseptic conditions, offering a sustainable approach to bio-based production.

18 sept. 202445 min read
Insights into the relative contribution of four precursors to 3-sulfanylhexan-1-ol and 3-sulfanylhexylacetate biogenesis during fermentation

This study by researchers from the University of Auckland delves into the complex formation of 3-sulfanylhexan-1-ol (3SH) and 3-sulfanylhexyl acetate (3SHA), two essential contributors to white wine aroma. Using isotopically labeled analogues, the team uncovered how non-volatile precursors present in grapes convert to these key aroma compounds during fermentation. This research offers fresh insights into wine chemistry and the role of specific precursors in enhancing desirable wine aromas.

13 sept. 20246 min read
Oxidative refolding by copper-catalyzed air oxidation consistently increases the homogeneity of a novel interleukin-2 mutein

In this study, researchers have optimized the purification of IL-2 no-alpha mutein using copper-catalyzed air oxidation. This process, using the INFORS HT Techfors pilot bioreactor, improves the homogeneity and biological activity of the IL-2 agonist, which shows promise in Phase I/II trials for cancer treatment.

13 sept. 202440 min read
Diamide-based screening method for the isolation of improved oxidative stress tolerance phenotypes in Bacillus mutant libraries

This study, on ASM Journals, discusses promising methods to selectively identify phenotypes in B. subtilis with improved tolerance toward oxidative and disulfide-associated stress. The Multitron incubator shaker was used to quickly screen large libraries of transposon mutants for those bacteria that show enhanced tolerance towards oxidative stress.

13 sept. 202410 min read
Rapid and simultaneous screening of pathway designs and chassis organisms, applied to engineered living materials

This scientific research paper on ScienceDirect highlights the Multitron incubator shaker as a tool for enhancing productivity of simultaneous screening of genetic designs and chassis during the build step of metabolic engineering.

13 sept. 202435 min read
Robust, fully quantifiable and scalable bioprocess utilizing spent sulfite liquor with Corynebacterium glutamicum

This study, published on ScienceDirect, aimed to revolutionize bioproduction by developing a cost-effective, robust, and scalable platform using a novel approach with C. glutamicum and UF-SSL. This research eliminates costly media additives and energy-intensive detoxification steps, paving the way for more efficient and sustainable industrial ethanol production.

13 sept. 202430 min read
Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture

The goal of this research. conduced at Karolinska Institutet in Stockholm, Sweden, was to improve the productivity of human Bri2 BRICHOS domain production. The human Bri2 BRICHOS domain inhibits amyloid formation and toxicity and could be used as a therapeutic agent against amyloid diseases, such as alzheimers disease. 

13 sept. 202432 min read
Metabolic control analysis enabled the improvement of the L-cysteine production process with Escherichia coli

This research that was conducted at the Technical University of Munich, where scientists utilized an INFORS HT Techfors pilot bioreactor to evaluate and refine the expression of L-cysteine (amino acid widely used in pharmaceutical, food, feed, and cosmetic industries) synthases, achieving a productivity improvement of ~70%.

13 sept. 202435 min read
Non-inhibitory levels of oxygen during cultivation increase freeze-drying stress tolerance in Limosilactobacillus reuteri DSM 17938

This research was done by Nikhil Seshagiri Rao, Ph.D. and a team of scientists at Lund University in Sweden, published in the journal, Frontiers in Microbiology, where they utilized the INFORS HT Minifors bioreactor system with eve® bioprocess platform software to evaluate the effects of oxygen during cultivation on freeze-drying stress tolerance.

13 sept. 202426 min read
Development of a unique rapid test to detect antibodies directed against an extended RBD of SARS-CoV-2 spike protein

Researchers at University of Applied Sciences and Arts Northwestern Switzerland FHNW worked to develop a rapid test that measures patient immune protection from SARS-CoV-2, resulting from prior infection or vaccination. Their work utilized INFORS HT's Techfors-S pilot bioreactor.

18 sept. 202445 min read
Insights into the relative contribution of four precursors to 3-sulfanylhexan-1-ol and 3-sulfanylhexylacetate biogenesis during fermentation

This study by researchers from the University of Auckland delves into the complex formation of 3-sulfanylhexan-1-ol (3SH) and 3-sulfanylhexyl acetate (3SHA), two essential contributors to white wine aroma. Using isotopically labeled analogues, the team uncovered how non-volatile precursors present in grapes convert to these key aroma compounds during fermentation. This research offers fresh insights into wine chemistry and the role of specific precursors in enhancing desirable wine aromas.

13 sept. 20246 min read
Oxidative refolding by copper-catalyzed air oxidation consistently increases the homogeneity of a novel interleukin-2 mutein

In this study, researchers have optimized the purification of IL-2 no-alpha mutein using copper-catalyzed air oxidation. This process, using the INFORS HT Techfors pilot bioreactor, improves the homogeneity and biological activity of the IL-2 agonist, which shows promise in Phase I/II trials for cancer treatment.

13 sept. 202440 min read
Diamide-based screening method for the isolation of improved oxidative stress tolerance phenotypes in Bacillus mutant libraries

This study, on ASM Journals, discusses promising methods to selectively identify phenotypes in B. subtilis with improved tolerance toward oxidative and disulfide-associated stress. The Multitron incubator shaker was used to quickly screen large libraries of transposon mutants for those bacteria that show enhanced tolerance towards oxidative stress.

13 sept. 202410 min read
Rapid and simultaneous screening of pathway designs and chassis organisms, applied to engineered living materials

This scientific research paper on ScienceDirect highlights the Multitron incubator shaker as a tool for enhancing productivity of simultaneous screening of genetic designs and chassis during the build step of metabolic engineering.

13 sept. 202435 min read
Robust, fully quantifiable and scalable bioprocess utilizing spent sulfite liquor with Corynebacterium glutamicum

This study, published on ScienceDirect, aimed to revolutionize bioproduction by developing a cost-effective, robust, and scalable platform using a novel approach with C. glutamicum and UF-SSL. This research eliminates costly media additives and energy-intensive detoxification steps, paving the way for more efficient and sustainable industrial ethanol production.

13 sept. 202430 min read
Expression of the human molecular chaperone domain Bri2 BRICHOS on a gram per liter scale with an E. coli fed-batch culture

The goal of this research. conduced at Karolinska Institutet in Stockholm, Sweden, was to improve the productivity of human Bri2 BRICHOS domain production. The human Bri2 BRICHOS domain inhibits amyloid formation and toxicity and could be used as a therapeutic agent against amyloid diseases, such as alzheimers disease. 

13 sept. 202432 min read
Metabolic control analysis enabled the improvement of the L-cysteine production process with Escherichia coli

This research that was conducted at the Technical University of Munich, where scientists utilized an INFORS HT Techfors pilot bioreactor to evaluate and refine the expression of L-cysteine (amino acid widely used in pharmaceutical, food, feed, and cosmetic industries) synthases, achieving a productivity improvement of ~70%.

13 sept. 202435 min read
Non-inhibitory levels of oxygen during cultivation increase freeze-drying stress tolerance in Limosilactobacillus reuteri DSM 17938

This research was done by Nikhil Seshagiri Rao, Ph.D. and a team of scientists at Lund University in Sweden, published in the journal, Frontiers in Microbiology, where they utilized the INFORS HT Minifors bioreactor system with eve® bioprocess platform software to evaluate the effects of oxygen during cultivation on freeze-drying stress tolerance.

13 sept. 202426 min read
Development of a unique rapid test to detect antibodies directed against an extended RBD of SARS-CoV-2 spike protein

Researchers at University of Applied Sciences and Arts Northwestern Switzerland FHNW worked to develop a rapid test that measures patient immune protection from SARS-CoV-2, resulting from prior infection or vaccination. Their work utilized INFORS HT's Techfors-S pilot bioreactor.

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